Property Summary

NCBI Gene PubMed Count 43
PubMed Score 25.75
PubTator Score 27.64

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Parkinson Disease 105
Disease Target Count P-value
juvenile dermatomyositis 1189 1.63798554024788E-5
ovarian cancer 8492 4.97890132796056E-5
nasopharyngeal carcinoma 1056 6.48360567614897E-5
atypical teratoid / rhabdoid tumor 4369 2.9425712241603E-4
medulloblastoma, large-cell 6234 5.7895960374793E-4
osteosarcoma 7933 0.00112407703117859
Waldenstrons macroglobulinemia 765 0.00199082022911068
adult high grade glioma 2148 0.00227094297342234
Multiple myeloma 1328 0.0102063929387562
pancreatic cancer 2300 0.0116892181830268
pancreatic carcinoma 567 0.0116892181830272
hereditary spastic paraplegia 313 0.0180217834266655
group 4 medulloblastoma 1875 0.0229013328520834
subependymal giant cell astrocytoma 2287 0.0351755679925347
Breast cancer 3099 0.044717838733487
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0477665410727611
Disease Target Count Z-score Confidence
Parkinson's disease 364 0.0 2.0



Accession Q9H1E3 Q54AC0 Q5PXE7 Q9H1D6 Q9H723
Symbols JC7


  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (20)

26968889 NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC
26323318 The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression.
25119009 We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67, thus allowing more precise assessment of tumor proliferation potential.
25116364 NUCKS1 expression did not increase Tat nuclear localization.
25116364 Overexpression of NUCKS1 moderately induces HIV-1 production with increased release of p24 without PMA stimulation in latently infected cells
24931609 NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators.
24819170 NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma
24568505 NUCKS-1 overexpression is associated with obesity and with breast cancer.
24284105 Authors suggest that NUCKS is involved in cellular responses following PDT.
24140890 The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.

AA Sequence

EPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED                                         211 - 243

Text Mined References (59)

PMID Year Title
26968889 2016 Identification of NUCKS1 as a putative oncogene and immunodiagnostic marker of hepatocellular carcinoma.
26323318 2015 NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
25434496 2015 Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
25119009 2014 The comparison of nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) with Ki67 proliferation marker expression in common skin tumors.
25116364 2014 NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter.
25064009 2014 Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
24952745 2014 Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
24931609 2014 NUCKS is a positive transcriptional regulator of insulin signaling.
24842889 2014 Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.