Tbio GZF1 GDNF-inducible zinc finger protein 1

Protein Summary

Description

Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.

Uniprot Accession IDs

• Q9H116
• A8K199
• B2RBC3
• B3KPL4
• B4DF58
• D3DW39
• Q54A22
• Q96N08
• Q9BQK9
• Q9H117
• Q9H6W6

Gene Name

• GZF1

Ensembl ID

• ENST00000338121
• ENSP00000338290
• ENSG00000125812
• ENST00000377051
• ENSP00000366250

Symbol

• ZBTB23
• ZNF336
• JLSM
• ZBTB23
• ZNF336

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
protein domain	0.85
virus perturbation	0.79
cell line	0.75
tissue sample	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.14   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.14   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0