Tchem SIK2 Serine/threonine-protein kinase SIK2

Protein Summary

Description

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Uniprot Accession IDs

• Q9H0K1
• A8K5B8
• B0YJ94
• O94878
• Q17RV0
• Q6AZE2
• Q76N03
• Q8NCV7
• Q96CZ8

Gene Name

• SIK2

Ensembl ID

• ENST00000304987
• ENSP00000305976
• ENSG00000170145

Symbol

• KIAA0781
• QIK
• SNF1LK2
• QIK
• SIK-2
• SNF1LK2
• LOH11CR1I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
molecular function	0.95
protein domain	0.92
virus perturbation	0.92
interacting protein	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Sik2

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / Qik Subfamily / Serine/threonine-protein Kinase Sik2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.52   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.52   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2