Property Summary

NCBI Gene PubMed Count 30
PubMed Score 4.64
PubTator Score 6.80

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
lung carcinoma 2844 6.24181109652863E-34
astrocytoma 1493 1.92436468841213E-20
oligodendroglioma 2849 5.49833609671635E-16
posterior fossa group B ependymoma 1530 1.67667989376692E-10
glioblastoma 5572 1.4449288614804E-9
pilocytic astrocytoma 3086 3.10339989797113E-6
atypical teratoid/rhabdoid tumor 1095 3.19523239618904E-6
pediatric high grade glioma 2712 4.4617264951617E-6
sonic hedgehog group medulloblastoma 1482 1.09096805344809E-5
Disease Target Count
SPOAN syndrome 2

Expression

  Differential Expression (9)

Disease log2 FC p
astrocytoma -1.100 0.000
glioblastoma -1.400 0.000
oligodendroglioma -1.200 0.000
posterior fossa group B ependymoma -1.700 0.000
sonic hedgehog group medulloblastoma -1.700 0.000
atypical teratoid/rhabdoid tumor -1.400 0.000
pediatric high grade glioma -1.200 0.000
pilocytic astrocytoma -1.300 0.000
lung carcinoma 1.200 0.000

Synonym

Accession Q9H0B6 A8MXL7 B2RDY4 Q9H9C8 Q9HA20 KLC 2
Symbols

Gene

PDB

3CEQ   3EDT  

  Ortholog (11)

Gene RIF (4)

PMID Text
26385635 a homozygous 216-bp deletion located at the non-coding upstream region of the KLC2 gene in patients with SPOAN syndrome causes overexpression of the gene
25668010 Results identified KLC2 as a novel target and of miR-125b in non-small-cell lung cancer (NSCLC) and show the oncogenic potential of KLC2 in the progression of NSCLC.
22470497 For the binding of cargos shared by KLC2, we propose a different site located within the groove but not involving N343.
19773350 Na,K-ATPase traffic toward the plasma membrane in alveolar epithelial cells is driven by kinesin-1, where KLC2 is the isoform regulating this process.

AA Sequence

MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIEL      1 - 70
GLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFM     71 - 140
SQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYAS    141 - 210
QGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPA    211 - 280
VAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRA    281 - 350
LEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREE    351 - 420
SKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDPASQTK    421 - 490
VVELLKDGSGRRGDRRSSRDMAGGAGPRSESDLEDVGPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEML    491 - 560
VKKLQGGTPQEPPNPRMKRASSLNFLNKSVEEPTQPGGTGLSDSRTLSSSSMDLSRRSSLVG            561 - 622
//

Text Mined References (38)

PMID Year Title
26884162 2016 The light chains of kinesin-1 are autoinhibited.
26385635 2015 Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome.
25668010 2015 High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22470497 2012 Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.
21926972 2011 Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
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