Tchem NUAK2 NUAK family SNF1-like kinase 2

Protein Summary

Description

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.

Uniprot Accession IDs

• Q9H093

Gene Name

• NUAK2

Ensembl ID

• ENST00000367157
• ENSP00000356125
• ENSG00000163545

Symbol

• OMPHK2
• SNARK
• SNARK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.95
small molecule	0.95
drug perturbation	0.87
transcription factor binding site profile	0.81

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Nuak Family Snf1-like Kinase 2

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / Nuak Subfamily / Nuak Family Snf1-like Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.77   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 252   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.77   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2