Tbio CLPB Caseinolytic peptidase B protein homolog

Protein Summary

Description

May function as a regulatory ATPase and be related to secretion/protein trafficking process. This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• Q9H078
• B4DXJ7
• B4DXP7
• B4DXW4
• E7EWN6
• F8W7P6
• Q8ND11
• Q9H8Y0

Gene Name

• CLPB

Ensembl ID

• ENST00000294053
• ENSP00000294053
• ENSG00000162129
• ENST00000340729
• ENSP00000340385
• ENST00000437826
• ENSP00000407296
• ENST00000538039
• ENSP00000441518

Symbol

• HSP78
• SKD3
• SKD3
• HSP78
• MGCA7
• ANKCLB
• MEGCANN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
transcription factor binding site profile	0.96
gene perturbation	0.92
protein domain	0.92

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 579.92   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 579.92   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0