Tbio TMEM126A Transmembrane protein 126A

Protein Summary

Description

The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q9H061
• B2R570
• E9PI16

Gene Name

• TMEM126A

Ensembl ID

• ENST00000304511
• ENSP00000306887
• ENSG00000171202
• ENST00000528105
• ENSP00000436590
• ENST00000532180
• ENSP00000434357

Symbol

• OPA7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
disease perturbation	0.83
virus perturbation	0.83
histone modification site profile	0.82
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.2   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.2   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0