Tbio LHPP Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Protein Summary

Description

Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).

Uniprot Accession IDs

• Q9H008
• B3KP20
• Q2TBE9
• Q5VUV9
• Q5VUW0
• hLHPP

Gene Name

• LHPP

Ensembl ID

• ENST00000368839
• ENSP00000357832
• ENSG00000107902
• ENST00000368842
• ENSP00000357835

Symbol

• HDHD2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.83
histone modification site profile	0.76
molecular function	0.7
transcription factor binding site profile	0.67
phenotype	0.63

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.47   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.47   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0