Property Summary

NCBI Gene PubMed Count 18
PubMed Score 265.83
PubTator Score 68.90

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Holoprosencephaly 52
Jaw Abnormalities 5
Disease Target Count P-value
glioblastoma multiforme 347 4.7327662708798E-17
ependymoma 2514 6.14814846086435E-14
malignant mesothelioma 3163 1.69629483189636E-8
pilocytic astrocytoma 3086 1.30138856802113E-5
atypical teratoid / rhabdoid tumor 4369 1.54533049277198E-5
ovarian cancer 8492 7.70099971349679E-4
osteosarcoma 7933 0.00231158795608862
active Crohn's disease 918 0.00233091466913656
nasopharyngeal carcinoma 1056 0.0052197122757635
progressive supranuclear palsy 674 0.011782667330612
active ulcerative colitis 477 0.0145714874110334
Breast cancer 3099 0.0284846274058571
primary pancreatic ductal adenocarcinoma 1271 0.0304804034596429
Disease Target Count Z-score Confidence
Cancer 2346 4.184 2.1


  Differential Expression (13)


Accession Q9GZX9 B2RE08 D3DUH9 Q8NBI7 Q96K46
Symbols TSG


  Ortholog (13)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid
Fruitfly EggNOG Inparanoid

Gene RIF (5)

26517884 Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.
23641068 these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.
21227728 mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies
19414861 interferes with BMP-mediated hepcidin expression and may act with GDF15 to dysregulate iron homeostasis in thalassemia syndromes.
17164348 Tsg functions as an agonist synergizing with TGF-beta to inhibit T-cell activation.

AA Sequence

YGSKTVKCMNCMF                                                             211 - 223

Text Mined References (20)

PMID Year Title
26517884 2015 The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.
25416956 2014 A proteome-scale map of the human interactome network.
23641068 2013 Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23064961 2013 GWAS of dental caries patterns in the permanent dentition.
21227728 2011 Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly.
19414861 2009 Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
17164348 2007 Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.