Property Summary

NCBI Gene PubMed Count 21
PubMed Score 25.91
PubTator Score 19.38

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
pilocytic astrocytoma 3086 3.74591922848296E-7
glioblastoma 5572 2.84271377255696E-5
pediatric high grade glioma 2712 2.90941082161602E-5
psoriasis 6685 9.96798773167284E-5
osteosarcoma 7933 0.00243098377426734


  Differential Expression (5)

Disease log2 FC p
psoriasis -1.600 0.000
osteosarcoma -1.539 0.002
glioblastoma 1.300 0.000
pediatric high grade glioma 1.100 0.000
pilocytic astrocytoma 1.100 0.000


Accession Q9GZU7 C9IYG0 Q7Z5Q3 Q7Z5Q4
Symbols NIF3



2GHQ   2GHT   1T9Z   1TA0   3L0B   3L0C   3L0Y   3PGL   4YGY   4YH1  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Zebrafish OMA Inparanoid

MLP Assay (6)

AID Type Active / Inconclusive / Inactive Description
493091 screening 2991 / 0 / 337938 uHTS Colorimetric assay for identification of inhibitors of Scp-1
493120 summary 0 / 0 / 0 Summary assay for small molecule Inhibitors of SCP-1
540281 screening 1487 / 0 / 965 Single concentration confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
540297 confirmatory 1000 / 0 / 11 Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
540313 screening 0 / 0 / 2452 Single concentration colorimetric interference counterscreen of uHTS hits for Scp-1 phosphatase
540329 other 378 / 0 / 1109 Differential Scanning Fluorimetry (Thermal Shift) Binding Assay for validation of Inhibitors of Scp-1 phosphatase

Gene RIF (11)

25893300 SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Serine-62.
25197063 CTDSP1 activity stabilizes REST in stem cells and ERK-dependent phosphorylation combined with Pin1 activity promotes REST degradation in neural progenitors.
25081999 hSCP1 may be an beta-O-linked N-acetylglucosamine modified protein in vivo.
24769477 SCP1 phosphatase substrate specificity: CdcA3 could be an enzymatic substrate for SCP1.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20222012 Captured the phosphoryl-aspartate intermediate in the crystal structure of a Scp1D206A mutant soaked with para-nitrophenyl phosphate (pNPP), providing strong evidence for the proposed mechanism.
19913121 Observational study of gene-disease association. (HuGE Navigator)
17085434 SCP1 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2.
15681389 results show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
12721286 SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation

AA Sequence


Text Mined References (25)

PMID Year Title
25893300 2016 SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62.
25416956 2014 A proteome-scale map of the human interactome network.
25197063 2014 C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
25081999 2014 In vivo putative O-GlcNAcylation of human SCP1 and evidence for possible role of its N-terminal disordered structure.
24769477 2014 A study of substrate specificity for a CTD phosphatase, SCP1, by proteomic screening of binding partners.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21348431 2011 Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor.