Property Summary

NCBI Gene PubMed Count 55
PubMed Score 105.44
PubTator Score 60.84

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
breast carcinoma 1614 1.73899537456794E-30
ovarian cancer 8492 5.63171832409281E-22
Breast cancer 3099 1.4053231647301E-10
osteosarcoma 7933 9.23917388251838E-5
psoriasis 6685 9.96269756903941E-5
nephrosclerosis 329 1.08158429915417E-4
malignant mesothelioma 3163 1.19378635557135E-4
chronic lymphocytic leukemia 244 1.75293813148379E-4
lung cancer 4473 2.18810815466282E-4
invasive ductal carcinoma 2950 2.63115642742095E-4
tuberculosis 1563 3.39462974858516E-4
atypical teratoid / rhabdoid tumor 4369 3.51500205797023E-4
group 4 medulloblastoma 1875 4.85416153586597E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 5.99200943627728E-4
adrenocortical carcinoma 1427 0.0010857916554967
lung carcinoma 2844 0.00114899873759219
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00138456005411815
Atopic dermatitis 944 0.00172390601728148
interstitial cystitis 2299 0.00346644372598372
urothelial carcinoma 318 0.0053544623496175
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00609281900959505
oligodendroglioma 2849 0.00741222879163259
ductal carcinoma in situ 1745 0.0100737956381846
type I diabetes mellitus 22 0.0126900061770955
aldosterone-producing adenoma 664 0.0220768650305206
gastric carcinoma 832 0.0307545241490289
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0391853197804683
Disease Target Count Z-score Confidence
Atherosclerosis 275 0.0 2.0
Cardiovascular system disease 194 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 3.342 1.7



Accession Q9GZP0 A8K9T6 Q9BWV5 PDGF-D
Symbols IEGF


PANTHER Protein Class (2)

  Ortholog (12)

 GWAS Trait (1)

Gene RIF (41)

26362023 polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population
26157007 Novel findings reveal a new paradigm in matriptase activation involving PDGF-D-specific signal transduction leading to extracellular acidosis.
25760076 PDGF-D expression is associated with miR-106a and Twist1 in HCC patients
25391964 PDGFD-PDGFRbeta signalling is required for human neocortical development and local production of growth factors by radial glia supports the expanded germinal region and progenitor heterogeneity of species with large brains
25333347 PDGFD, CDH1 and SLIT2 are upregulated in low grade meningiomas and schwannomas compared with healthy tissue.
25332166 PDGF-D is highly expressed by ASCs, where it acts as a potent mitogenic factor.
24938433 PDGF-DD secreted by gastric cancer derived mesenchymal stem cells is capable of promoting gastric cancer cell progression in vitro and in vivo.
24870786 Compared with matched normal endometrial cases, PDGF-D was up-regulated in endometrial cancer. Expression of PDGF-D protein, found in 78% of the cases, was associated with nonendometrioid histologic type.
24646915 Data suggest that targeting platelet-derived growth factor-D as a strategy for endometrial cancer treatment.
24158561 PDGF-D is highly expressed in gemcitabine resistant (GR) liver neoplasm cells. Furthermore, down-regulation of PDGF-D in GR cells led to partial reversal of the EMT phenotype.

AA Sequence

DIQLDHHERCDCICSSRPPR                                                      351 - 370

Text Mined References (59)

PMID Year Title
26362023 2016 A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.
26157007 2016 Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.
25760076 2015 The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells.
25391964 2014 Radial glia require PDGFD-PDGFR? signalling in human but not mouse neocortex.
25343990 2015 Genome-wide association study of selenium concentrations.
25333347 2014 Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue.
25332166 2015 Functional regulation of adipose-derived stem cells by PDGF-D.
24938433 2014 Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression.
24870786 2014 Overexpression of platelet-derived growth factor-D as a poor prognosticator in endometrial cancer.
24646915 2014 Over-expression of platelet-derived growth factor-D promotes tumor growth and invasion in endometrial cancer.