Tbio PRSS22 Brain-specific serine protease 4

Protein Summary

Description

Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9GZN4
• O43342
• Q6UXE0
• BSSP-4

Gene Name

• PRSS22

Ensembl ID

• ENST00000161006
• ENSP00000161006
• ENSG00000005001
• ENST00000642189
• ENSP00000495133
• ENSG00000282937
• ENST00000645000
• ENSP00000496223

Symbol

• BSSP4
• PRSS26
• BSSP-4
• SP001LA
• hBSSP-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
kinase perturbation	0.66
protein domain	0.58
cell type or tissue	0.56
disease perturbation	0.56

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Brain-specific Serine Protease 4

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Brain-specific Serine Protease 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.2   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.2   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0