| Tdark | Olfactory receptor 2H1 |
Odorant receptor.
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.4e-10 |
| osteosarcoma | 7950 | 2.8e-05 |
| medulloblastoma, large-cell | 6241 | 6.5e-05 |
| ulcerative colitis | 1819 | 6.9e-05 |
| adult high grade glioma | 3801 | 6.6e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.7e-03 |
| Multiple Sclerosis | 540 | 4.3e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Rheumatoid arthritis | 1191 | 0.0 | 2.3 |
| Type 1 diabetes mellitus | 109 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.300 | 6.6e-04 |
| atypical teratoid / rhabdoid tumor | 1.100 | 3.7e-03 |
| medulloblastoma, large-cell | 1.600 | 6.5e-05 |
| Multiple Sclerosis | 1.500 | 4.3e-03 |
| osteosarcoma | 1.095 | 2.8e-05 |
| ovarian cancer | 1.100 | 1.4e-10 |
| ulcerative colitis | -1.300 | 6.9e-05 |
MVNQSSPMGFLLLGFSEHPALERTLFVVVFTSYLLTLVGNTLIILLSVLYPRLHSPMYFFLSDLSFLDLC 1 - 70 FTTSCVPQMLVNLWGPKKTISFLGCSVQLFIFLSLGTTECILLTVMAFDRYVAVCQPLHYATIIHPRLCW 71 - 140 QLASVAWVMSLVQSIVQTPSTLHLPFCPHQQIDDFLCEVPSLIRLSCGDTSYNEIQLAVSSVIFVVVPLS 141 - 210 LILASYGATAQAVLRINSATAWRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPYAQGRGKFFGLFYAVGT 211 - 280 PSLNPLVYTLRNKEIKRALRRLLGKERDSRESWRAA 281 - 316 //
