Tbio BHLHE41 Class E basic helix-loop-helix protein 41

Protein Summary

Description

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• Q9C0J9
• A2I2N8
• bHLHe41

Gene Name

• BHLHE41

Ensembl ID

• ENST00000242728
• ENSP00000242728
• ENSG00000123095

Symbol

• BHLHB3
• DEC2
• SHARP1
• DEC2
• hDEC2
• BHLHB3
• SHARP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
small molecule perturbation	0.8
transcription factor binding site profile	0.8
PubMedID	0.69
transcription factor	0.69

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Class E Basic Helix-loop-helix Protein 41

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Class E Basic Helix-loop-helix Protein 41

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.78   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 367   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.78   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0