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Tbio
SRCIN1
SRC kinase signaling inhibitor 1

Protein Summary
Description
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615049
  • ENSP00000480869
  • ENSG00000273608
  • ENST00000617146
  • ENSP00000484715
  • ENSG00000277363

Symbol
  • KIAA1684
  • P140
  • P140
  • SNIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
biological process
0.82
cell type or tissue
0.79
transcription factor
0.78
hub protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.96   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.96   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0