Tbio TTYH3 Protein tweety homolog 3

Protein Summary

Description

Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9C0H2
• A4D201
• B7WP98
• Q6L749
• Q6ZVG3
• Q8TEG6
• hTTY3

Gene Name

• TTYH3

Ensembl ID

• ENST00000258796
• ENSP00000258796
• ENSG00000136295
• ENST00000403167
• ENSP00000385015
• ENST00000407643
• ENSP00000385316

Symbol

• KIAA1691

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.8
transcription factor perturbation	0.74
transcription factor binding site profile	0.7
molecular function	0.63
cellular component	0.62

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Anion Channel / Protein Tweety Homolog 3

DTO Classes

Protein / Ion Channel / Anion Channel Tweety (Tweety) Family / Protein Tweety Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.17   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0