Property Summary

NCBI Gene PubMed Count 12
PubMed Score 11.07
PubTator Score 6.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
osteosarcoma 7933 8.43523139160398E-5
adrenocortical carcinoma 1427 3.38187118229027E-4
ovarian cancer 8492 5.85203525252303E-4
acute quadriplegic myopathy 1157 0.00194965320849941
pituitary cancer 1972 0.00237908264105935
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00260649536642295
aldosterone-producing adenoma 664 0.00532838907907992
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00832195462373149
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00840666194156284
Disease Target Count Z-score Confidence
nail-patella syndrome 16 4.341 2.2
Subacute thyroiditis 5 4.208 2.1

Expression

Synonym

Accession Q9C0E8 B7ZLA8 Q2M2V8 Q2YD99 Q658W8 Q8N5V9 Q96MS5
Symbols Ul
LNP
LNP1
KIAA1715
ulnaless

Gene

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG
Dog OMA EggNOG
Horse OMA EggNOG
Cow OMA EggNOG
Pig OMA EggNOG
Opossum OMA EggNOG
Platypus OMA EggNOG
Xenopus OMA EggNOG

 GO Function (1)

Gene RIF (3)

PMID Text
25548161 used live cell imaging to show that mammalian Lnp1 affects endoplasmic reticulum junction mobility and hence network dynamics
24223779 Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark.
22729086 Propose that Lnp1p and Sey1p act antagonistically to balance endoplasmic reticular polygonal network formation.

AA Sequence

MGGLFSRWRTKPSTVEVLESIDKEIQALEEFREKNQRLQKLWVGRLILYSSVLYLFTCLIVYLWYLPDEF      1 - 70
TARLAMTLPFFAFPLIIWSIRTVIIFFFSKRTERNNEALDDLKSQRKKILEEVMEKETYKTAKLILERFD     71 - 140
PDSKKAKECEPPSAGAAVTARPGQEIRQRTAAQRNLSPTPASPNQGPPPQVPVSPGPPKDSSAPGGPPER    141 - 210
TVTPALSSNVLPRHLGSPATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALICQQCF    211 - 280
SHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQVVEGSSSVGPLPSGSVLSSDNQFN    281 - 350
EESLEHDVLDDNTEQTDDKIPATEQTNQVIEKASDSEEPEEKQETENEEASVIETNSTVPGADSIPDPEL    351 - 420
SGESLTAE                                                                  421 - 428
//

Text Mined References (22)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25548161 2015 Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24223779 2013 Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22729086 2012 ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p.
22699663 2012 Genome-wide association study of periodontal pathogen colonization.
21269460 2011 Initial characterization of the human central proteome.
20213681 2010 Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.
More...