Tdark CIPC CLOCK-interacting pacemaker

Protein Summary

Description

Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.

Uniprot Accession IDs

• Q9C0C6
• B2RCI1
• Q8N389
• Q8NDZ1

Gene Name

• CIPC

Ensembl ID

• ENST00000361786
• ENSP00000355319
• ENSG00000198894

Symbol

• KIAA1737
• KIAA1737

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.95
histone modification site profile	0.83
transcription factor	0.8
transcription factor perturbation	0.68
cell type or tissue	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.74   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.74   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0