Tdark | Palmitoyltransferase ZDHHC5 |
Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 0.00121701134841947 |
COPD | 116 | 0.00262896065724821 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0075041540761399 |
Disease | log2 FC | p |
---|---|---|
intraductal papillary-mucinous neoplasm ... | 1.200 | 0.008 |
COPD | -1.100 | 0.003 |
ovarian cancer | 1.400 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
PMID | Text |
---|---|
25573953 | Data indicate that DHHC5 has oncogenic capacity and contributes to tumor formation in non-small cell lung cancer. |
21820437 | ZDHHC5 and SSTR5 are colocalized at the plasma membrane and coexpression of ZDHHC5 increased palmitoylation of SSTR5 whereas knock-down of endogenous ZDHHC5 by siRNAs decreased it. |
19801377 | Data show that palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain. |
MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVSPAVPIYNAIMFLFVLANFSMATFMDP 1 - 70 GIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNC 71 - 140 IGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVL 141 - 210 VARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITV 211 - 280 KIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLGLATNEDSSLLAKDSPPTPT 281 - 350 MYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDP 351 - 420 LSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPE 421 - 490 PDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGR 491 - 560 EEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPLGRPAVPRFGKPDGLRGRGVGSPEPGPTAPY 561 - 630 LGRSMSYSSQKAQPGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGV 631 - 700 KKVSGVGGTTYEISV 701 - 715 //
PMID | Year | Title |
---|---|---|
25573953 | 2015 | Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5. |
25056061 | 2014 | Biological insights from 108 schizophrenia-associated genetic loci. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
24129315 | 2014 | Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
23034182 | 2012 | Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. |
22325201 | 2012 | Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. |
21820437 | 2011 | Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. |
21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
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