Property Summary

NCBI Gene PubMed Count 18
PubMed Score 2.65
PubTator Score 2.39

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (2)

Disease Z-score Confidence
osteosarcoma 7,933
psoriasis 6,685

Expression

  Differential Expression (2)

Disease log2 FC p
psoriasis 4.400 0.000
osteosarcoma 1.267 0.000

Gene RIF (7)

PMID Text
25450970 TRIM15 may function as a tumor suppressor of colon cancer.
25015296 TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates.
20466734 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19851445 Observational study of gene-disease association. (HuGE Navigator)
18248090 Downregulation of TRIM11 and TRIM15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells.
18248090 Fluorescence microscope analysis demonstrates a reduction of HIV-1 Gag fluorescence at the plasma membrane in cells containing cytoplasmic TRIM15 bodies

AA Sequence

MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPM      1 - 70
APVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTE     71 - 140
RDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVS    141 - 210
EEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRM    211 - 280
FSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHR    281 - 350
WQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALD    351 - 420
YEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG                             421 - 465
//

Text Mined References (19)

PMID Year Title
25450970 2015 Role of the focal adhesion protein TRIM15 in colon cancer development.
25416956 2014 A proteome-scale map of the human interactome network.
25015296 2014 TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.
24489884 2014 Genome-wide association study of proneness to anger.
23077300 2013 TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
20466734 2010 Refining the association of MHC with multiple sclerosis in African Americans.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19851445 2009 High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
18248090 2008 TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
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