Property Summary

NCBI Gene PubMed Count 26
Grant Count 9
R01 Count 6
Funding $455,754
PubMed Score 20.84
PubTator Score 15.18

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (2)

Disease log2 FC p
Breast cancer 3.200 0.028
ovarian cancer 2.100 0.000

Gene RIF (11)

PMID Text
26691508 Dpy30 role in cellular reprogramming and its interactions with Set1 complex
26147337 results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer
25561738 these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo.
25542209 Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS
25139354 The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
24690193 A deletion mutation and reduced DPY30 expression in a Spastic Paraplegia type 4 Japanese family.
23872946 DPY30 regulates pathways in cellular senescence through ID protein expression.
22231628 determination of the minimum motif of Ash2L that is required for DPY30 interaction; a structural model for the Ash2L-DPY30 interaction
20857310 First report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree.
19481096 The DPY-30 C-terminal domain structure, harboring the conserved DPY-30 motif, is composed of two alpha-helices linked by a sharp loop and forms a typical X-type four-helix bundle required for dimer formation.
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AA Sequence

MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLA      1 - 70
VLAKERPPNPIEFLASYLLKNKAQFEDRN                                              71 - 99
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Text Mined References (33)

PMID Year Title
26691508 2015 Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.
26147337 2015 Roles of DPY30 in the Proliferation and Motility of Gastric Cancer Cells.
25561738 2015 Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
25542209 2015 Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation.
25416956 2014 A proteome-scale map of the human interactome network.
25139354 2014 The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
24690193 2014 Novel SPAST deletion and reduced DPY30 expression in a Spastic Paraplegia type 4 kindred.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24182552 2014 Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
23872946 2013 DPY30 regulates pathways in cellular senescence through ID protein expression.
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