Tbio TRIM31 E3 ubiquitin-protein ligase TRIM31

Protein Summary

Description

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q9BZY9
• A6NLX6
• A9R9Q4
• Q53H52
• Q5RI37
• Q5SRJ7
• Q5SRJ8
• Q5SS28
• Q96AK4
• Q96AP8
• Q99579
• Q9BZY8

Gene Name

• TRIM31

Ensembl ID

• ENST00000357569
• ENSP00000350182
• ENSG00000137397
• ENST00000376734
• ENSP00000365924
• ENSG00000204616
• ENST00000433864
• ENSP00000390551
• ENSG00000233573
• ENST00000445679
• ENSP00000409501
• ENSG00000224168
• ENST00000449412
• ENSP00000398677
• ENSG00000223531
• ENST00000453266
• ENSP00000391685
• ENSG00000225130
• ENST00000551027
• ENSP00000446675

Symbol

• C6orf13
• RNF
• RNF
• HCG1
• HCGI
• C6orf13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
virus perturbation	0.68
gene perturbation	0.67
phenotype	0.63
biological process	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.16   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.16   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0