Property Summary

NCBI Gene PubMed Count 21
PubMed Score 12.39
PubTator Score 12.74

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
breast carcinoma 1614 2.53728921315692E-21
lung carcinoma 2844 3.74656288690845E-17
chronic lymphosyte leukemia 232 4.02238147589891E-9
pilocytic astrocytoma 3086 1.65160513980093E-7
ependymoma 2514 2.12034706891669E-7
lung cancer 4473 1.21850599064198E-6
colon cancer 1475 1.46112688029557E-5
ovarian cancer 8492 2.40117065586164E-5
primary pancreatic ductal adenocarcinoma 1271 6.30678580768293E-5
malignant mesothelioma 3163 9.37968012273273E-5
adult high grade glioma 2148 1.19245508234212E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.56888562030469E-4
pancreatic cancer 2300 1.87880448432658E-4
atypical teratoid/rhabdoid tumor 1095 1.95451178877216E-4
ulcerative colitis 2087 1.98369757142556E-4
Breast cancer 3099 5.48766104781905E-4
Pick disease 1893 6.72200554419188E-4
glioblastoma 5572 0.00142504278937266
dermatomyositis 967 0.0017923051052367
tuberculosis and treatment for 6 months 686 0.00245691099489151
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00268317691809005
Rheumatoid Arthritis 1171 0.0029880931822906
medulloblastoma, large-cell 6234 0.00329224765080093
psoriasis 6685 0.00489252146804867
subependymal giant cell astrocytoma 2287 0.00529352693814589
diabetes mellitus 1663 0.00581850179243405
group 3 medulloblastoma 2254 0.0079220426718058
Polycystic Ovary Syndrome 335 0.0131231935203298
chronic kidney disease 90 0.0177152391322023
X-linked cerebral adrenoleukodystrophy 115 0.0224596997380965
acute myeloid leukemia 785 0.0241950791995223
aldosterone-producing adenoma 664 0.0312096424023132
invasive ductal carcinoma 2950 0.0429151502562184
osteosarcoma 7933 0.046316961507255

Expression

Synonym

Accession Q9BZQ8 Q2TTR2 Q5TEM8 Q8TEI5 Q9H593 Q9H9Y8 Q9HCB9
Symbols GIG39
NIBAN
C1orf24

Gene

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid

Gene RIF (6)

PMID Text
26317551 Data suggest that decreasing C1orf24 protein levels by restoring microRNA miR-106b function may have therapeutic implications.
22157935 DDIT3, STT3A, ARG2 and FAM129A immunohistochemistry does not appear to be useful in the diagnosis of thyroid follicular neoplasias, as they do not reliably distinguish follicular thyroid carcinoma from follicular thyroid adenoma.
21520112 Gene-expression data suggest a difference in expression between STT3A, Clorf24, and TFF3 in FAs versus carcinomas that may be detected from an FNA sample. Findings must be validated from preoperative FNAs in larger numbers
19536772 The expression of Niban frequently begins in the early stages of head and neck squamous carcinoma and remains upregulated throughout the carcinogenic process. Niban may be a good molecular marker of HNSCC.
19240061 Observational study of gene-disease association. (HuGE Navigator)
16949643 Niban expression is up-regulated in various types of thyroid tumors.

AA Sequence

MGGSASSQLDEGKCAYIRGKTEAAIKNFSPYYSRQYSVAFCNHVRTEVEQQRDLTSQFLKTKPPLAPGTI      1 - 70
LYEAELSQFSEDIKKWKERYVVVKNDYAVESYENKEAYQRGAAPKCRILPAGGKVLTSEDEYNLLSDRHF     71 - 140
PDPLASSEKENTQPFVVLPKEFPVYLWQPFFRHGYFCFHEAADQKRFSALLSDCVRHLNHDYMKQMTFEA    141 - 210
QAFLEAVQFFRQEKGHYGSWEMITGDEIQILSNLVMEELLPTLQTDLLPKMKGKKNDRKRTWLGLLEEAY    211 - 280
TLVQHQVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNYLIGKIKAMVAQPAEKSCLESVQPFLASI    281 - 350
LEELMGPVSSGFSEVRVLFEKEVNEVSQNFQTTKDSVQLKEHLDRLMNLPLHSVKMEPCYTKVNLLHERL    351 - 420
QDLKSRFRFPHIDLVVQRTQNYMQELMENAVFTFEQLLSPHLQGEASKTAVAIEKVKLRVLKQYDYDSST    421 - 490
IRKKIFQEALVQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILHQILLDETLKVIKEA    491 - 560
AILKKHNLFEDNMALPSESVSSLTDLKPPTGSNQASPARRASAILPGVLGSETLSNEVFQESEEEKQPEV    561 - 630
PSSLAKGESLSLPGPSPPPDGTEQVIISRVDDPVVNPVATEDTAGLPGTCSSELEFGGTLEDEEPAQEEP    631 - 700
EPITASGSLKALRKLLTASVEVPVDSAPVMEEDTNGESHVPQENEEEEEKEPSQAAAIHPDNCEESEVSE    701 - 770
REAQPPCPEAHGEELGGFPEVGSPASPPASGGLTEEPLGPMEGELPGEACTLTAHEGRGGKCTEEGDASQ    771 - 840
QEGCTLGSDPICLSESQVSEEQEEMGGQSSAAQATASVNAEEIKVARIHECQWVVEDAPNPDVLLSHKDD    841 - 910
VKEGEGGQESFPELPSEE                                                        911 - 928
//

Text Mined References (27)

PMID Year Title
26317551 2015 microRNA-106b-mediated down-regulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer.
25807930 2015 Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22510990 2012 AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
22157935 2012 The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors.
21520112 2011 STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates.
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