| Tbio | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).
Comments
| Disease | Target Count |
|---|---|
| Peripheral Neuropathy | 303 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung carcinoma | 413 | 1.14970150002597E-24 |
| lung adenocarcinoma | 2714 | 1.55676737657196E-11 |
| posterior fossa group B ependymoma | 1530 | 9.12936924877949E-8 |
| ovarian cancer | 8492 | 1.49473056044207E-6 |
| osteosarcoma | 7933 | 3.02767382410341E-6 |
| tuberculosis | 1563 | 6.02481840465323E-5 |
| cystic fibrosis | 1670 | 9.4391686722323E-5 |
| sonic hedgehog group medulloblastoma | 1482 | 1.30836162077991E-4 |
| glioblastoma | 5572 | 4.65732090289763E-4 |
| atypical teratoid / rhabdoid tumor | 4369 | 5.77398048281393E-4 |
| invasive ductal carcinoma | 2950 | 8.47254064324989E-4 |
| primary pancreatic ductal adenocarcinoma | 1271 | 0.0012312959194159 |
| primitive neuroectodermal tumor | 3031 | 0.00156721613771789 |
| pediatric high grade glioma | 2712 | 0.00223617907289467 |
| pancreatic cancer | 2300 | 0.00317174141845766 |
| progressive supranuclear palsy | 674 | 0.00771579372567038 |
| Breast cancer | 3099 | 0.0285527072041684 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Vogt-Koyanagi-Harada disease | 8 | 3.858 | 1.9 |
| Subacute thyroiditis | 5 | 3.059 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.500 | 0.000 |
| osteosarcoma | 1.811 | 0.000 |
| posterior fossa group B ependymoma | 1.800 | 0.000 |
| cystic fibrosis | -1.156 | 0.000 |
| atypical teratoid / rhabdoid tumor | 2.700 | 0.001 |
| sonic hedgehog group medulloblastoma | 1.700 | 0.000 |
| primitive neuroectodermal tumor | 1.300 | 0.002 |
| primary pancreatic ductal adenocarcinoma | 1.643 | 0.001 |
| tuberculosis | 1.200 | 0.000 |
| Breast cancer | 2.200 | 0.029 |
| lung adenocarcinoma | -1.100 | 0.000 |
| pediatric high grade glioma | 1.100 | 0.002 |
| non-small cell lung carcinoma | -1.200 | 0.000 |
| progressive supranuclear palsy | -1.600 | 0.008 |
| invasive ductal carcinoma | -1.300 | 0.001 |
| ovarian cancer | 2.100 | 0.000 |
| pancreatic cancer | 1.400 | 0.003 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 23333304 | HIV-1 Vif downregulates the expression of uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) in Vif-expression T cells |
| 22407486 | The down-regulation of APIP and UACA expression suggests that the threshold to activate the apoptosome apparatus may be decreased in non-small cell lung cancer cells. |
| 19240061 | Observational study of gene-disease association. (HuGE Navigator) |
| 15358194 | UACA is a novel candidate for eye muscle autoantigens in thyroid-associated ophthalmopathy |
MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRS 1 - 70 VFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHD 71 - 140 AAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEY 141 - 210 GCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHM 211 - 280 QDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKS 281 - 350 LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 351 - 420 SMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE 421 - 490 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEV 491 - 560 GKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 561 - 630 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGE 631 - 700 LGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 701 - 770 VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 771 - 840 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRN 841 - 910 LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 911 - 980 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 981 - 1050 IEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1051 - 1120 KKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREK 1121 - 1190 EEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEE 1191 - 1260 VLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1261 - 1330 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDV 1331 - 1400 QEALLQIIQMRQGLVC 1401 - 1416 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25218447 | 2014 | Uncovering global SUMOylation signaling networks in a site-specific manner. |
| 23932459 | 2014 | Genome-wide association study of lung function phenotypes in a founder population. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| 22407486 | 2012 | Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 19240061 | 2009 | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. |
| 19056867 | 2009 | Large-scale proteomics and phosphoproteomics of urinary exosomes. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| More... |
