OSBPL6
Oxysterol-binding protein-related protein 6
Protein Summary
Weakly binds 25-hydroxycholesterol. This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000190611
- ENSP00000190611
- ENSG00000079156
- ENST00000315022
- ENSP00000318723
- ENST00000357080
- ENSP00000349591
- ENST00000359685
- ENSP00000352713
- ENST00000392505
- ENSP00000376293
- ENST00000409045
- ENSP00000387248
- ENST00000409631
- ENSP00000386885
- ORP6
- ORP6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.97 | ||
trait | 0.86 | ||
histone modification site profile | 0.84 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.25 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.25 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0