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Tdark 39S ribosomal protein L37, mitochondrial

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 15
PubMed Score 2.00
PubTator Score 3.33

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
ovarian cancer 8520 1.3e-04
pancreatic ductal adenocarcinoma liver metastasis 1962 1.8e-02
Disease Target Count Z-score Confidence
Thrombophilia 38 3.042 1.5

Expression

  Differential Expression (2)

Disease log2 FC p
ovarian cancer 1.400 1.3e-04
pancreatic ductal adenocarcinoma liver m... -1.701 1.8e-02

Synonym

Accession Q9BZE1 Q96Q67 Q9BWR1 Q9P0P3 L37mt
Symbols L2mt
L37mt
MRPL2
RPML2
MRP-L2
MRP-L37

Gene

MRPL37

  Ortholog (13)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (8)

 GO Function (2)

 GO Component (4)

 GO Process (3)

 Compartment GO Term (40)

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 GWAS Trait (4)

 HCA RNA Cell Line (56)

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Pathway (6)

Protein-protein Interaction (18)

HSPD1   MRPL45   MRPL46   MRPL11   MRPL40   MRPL24   MRPL49   PDP1   MRPL27   MRPL55   MALSU1   MRPL47   MRPL16   MRPL13   MRPS30   DHRS4   MRPL51   DNLZ  

PDB (4)

Gene RIF (2)

AA Sequence 

MALASGPARRALAGSGQLGLGGFGAPRRGAYEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWL      1 - 70
ARPIFPPWDRGYKDPRFYRSPPLHEHPLYKDQACYIFHHRCRLLEGVKQALWLTKTKLIEGLPEKVLSLV     71 - 140
DDPRNHIENQDECVLNVISHARLWQTTEEIPKRETYCPVIVDNLIQLCKSQILKHPSLARRICVQNSTFS    141 - 210
ATWNRESLLLQVRGSGGARLSTKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKNDTGFQ    211 - 280
EGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLYGNDAKVLEQPVVVQSVGTDGR    281 - 350
VFHFLVFQLNTTDLDCNEGVKNLAWVDSDQLLYQHFWCLPVIKKRVVVEPVGPVGFKPETFRKFLALYLH    351 - 420
GAA                                                                       421 - 423
//

Text Mined References (18)

PMID Year Title