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Tbio
GLIS2
Zinc finger protein GLIS2

Protein Summary
Description
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262366
  • ENSP00000262366
  • ENSG00000126603
  • ENST00000433375
  • ENSP00000395547
  • ENST00000612491
  • ENSP00000484027
  • ENSG00000274636
  • ENST00000633051
  • ENSP00000488242

Symbol
  • NKL
  • NKL
  • NPHP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.74
tissue sample
0.68
molecular function
0.67
cellular component
0.64
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.76   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.76   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0