| Tbio | TBC1 domain family member 2A |
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
Comments
| Disease | Target Count |
|---|---|
| post-traumatic stress disorder | 45 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 3.9783412911769E-31 |
| osteosarcoma | 7933 | 4.53777973900096E-5 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.010879810918081 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -1.574 | 0.000 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 0.011 |
| lung carcinoma | -1.900 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| C. elegans | OMA Inparanoid |
| PMID | Text |
|---|---|
| 23562278 | Armus expression induces autophagosome accumulation in keratinocytes. |
| 23285084 | TBC1D2/Armus, a GAP of Rab7 GTPase, is reported as a novel target of miR-17. |
| 20944657 | Observational study of gene-disease association. (HuGE Navigator) |
| 20583170 | Observational study of gene-disease association. (HuGE Navigator) |
MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFF 1 - 70 YDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMK 71 - 140 RWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKH 141 - 210 LGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISF 211 - 280 AQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYL 281 - 350 AAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICK 351 - 420 LSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEK 421 - 490 ALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKY 491 - 560 DEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREH 561 - 630 RPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLL 631 - 700 AFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEK 701 - 770 LPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQ 771 - 840 NGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASR 841 - 910 RRAVSEGCASEDEVEGEA 911 - 928 //
| PMID | Year | Title |
|---|---|---|
| 23562278 | 2013 | The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. |
| 23285084 | 2012 | miR-17-5p regulates endocytic trafficking through targeting TBC1D2/Armus. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| 22354992 | 2012 | Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20944657 | 2011 | Replication of top markers of a genome-wide association study in multiple sclerosis in Spain. |
| 20583170 | 2010 | Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. |
| 20116244 | 2010 | Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. |
| 19077034 | 2009 | Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| More... |
