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Tbio
TBC1D2
TBC1 domain family member 2A

Protein Summary
Description
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342112
  • ENSP00000341567
  • ENSG00000095383
  • ENST00000375063
  • ENSP00000364203
  • ENST00000375064
  • ENSP00000364205
  • ENST00000375066
  • ENSP00000364207
  • ENST00000465784
  • ENSP00000481721

Symbol
  • PARIS1
  • PP8997
  • TBC1D2A
  • PARIS1
  • PARIS-1
  • TBC1D2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
histone modification site profile
0.78
tissue sample
0.61
gene perturbation
0.58
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.93   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.93   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0