Property Summary

NCBI Gene PubMed Count 12
PubMed Score 1.61
PubTator Score 1.67

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (19)

Disease log2 FC p
malignant mesothelioma -6.500 0.000
astrocytic glioma -2.700 0.009
oligodendroglioma -2.600 0.014
psoriasis -1.500 0.010
osteosarcoma -1.180 0.036
medulloblastoma -3.300 0.000
atypical teratoid / rhabdoid tumor -2.700 0.001
glioblastoma -2.800 0.000
medulloblastoma, large-cell -3.300 0.000
primitive neuroectodermal tumor -3.100 0.000
limb girdle muscular dystrophy 2A -1.352 0.000
Duchenne muscular dystrophy -1.222 0.000
Atopic dermatitis -1.700 0.001
pediatric high grade glioma -1.600 0.011
lung adenocarcinoma 2.400 0.007
ductal carcinoma in situ -1.200 0.004
invasive ductal carcinoma -1.300 0.019
ovarian cancer -1.600 0.000
pituitary cancer -1.900 0.000

Gene RIF (2)

PMID Text
22082156 Knockdown of leucine rich repeat containing 2 (LRRC2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence

MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIKEEWNFVAECRRKGIPQAVYCKNGFID      1 - 70
TSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYI     71 - 140
QLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFEL    141 - 210
SNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSML    211 - 280
NLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESERDRQHFDKEVMKAYIE    281 - 350
DLKERESVPSYTTKVSFSLQL                                                     351 - 371
//

Text Mined References (12)

PMID Year Title
21606681 2011 Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.
20616063 2011 Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
20420713 2010 Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
16432833 2006 Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12461651 2002 Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.
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