Tbio PARD6B Partitioning defective 6 homolog beta

Protein Summary

Description

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BYG5
• A2A2A7
• Q9Y510
• PAR-6 beta

Gene Name

• PARD6B

Ensembl ID

• ENST00000371610
• ENSP00000360672
• ENSG00000124171
• ENST00000396039
• ENSP00000379354

Symbol

• PAR6B
• PAR6B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.86
transcription factor perturbation	0.8
histone modification site profile	0.79
virus perturbation	0.79
transcription factor	0.71

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Partitioning Defective 6 Homolog Beta

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Partitioning Defective 6 Homolog Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0