| Tbio | Transmembrane protease serine 13 |
This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Comments
Property Summary
| NCBI Gene PubMed Count | 9 |
| Grant Count | 46 |
| R01 Count | 32 |
| Funding | $7,338,852.08 |
| PubMed Score | 52.14 |
| PubTator Score | 34.91 |
| Disease | Z-score | Confidence |
|---|---|---|
| Avian influenza 8 | 3.3 | 1.6 |
| medulloblastoma, large-cell 6,234 | ||
| ovarian cancer 8,484 |
| Disease | log2 FC | p |
|---|---|---|
| medulloblastoma, large-cell | 1.100 | 0.000 |
| ovarian cancer | -1.100 | 0.000 |
| PMID | Text |
|---|---|
| 25122802 | study demonstrates that two cellular serine proteases, DESC1 and MSPL, activate influenza viruses and emerging coronaviruses in cell culture and, because of their expression in human lung tissue, might promote viral spread in the infected host |
| 20977675 | results suggest that TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by HAI-1 |
| 20219906 | The authors report that serine proteases, MSPL and its splice variant TMPRSS13, are novel candidates for proteases processing HA proteins of highly pathogenic avian influenza (HPAI) viruses. |
| 17981585 | cloning of MSPL/TMPRSS13, which may play roles in the proteolytic processing of prohormones, precursors of growth factors, and also play roles in the pathogenicity of many viruses and bacteria in vivo |
MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQASPAGTPPGRAS 1 - 70 PGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVYLVRATPVGAVPIRSSPARSA 71 - 140 PATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVR 141 - 210 CDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHR 211 - 280 DFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHI 281 - 350 CGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 351 - 420 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYL 421 - 490 TPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMEV 491 - 560 RSLQQDTAPSRLGTSSGGDPGGAPRV 561 - 586 //
| PMID | Year | Title |
|---|---|---|
| 25122802 | 2014 | DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry. |
| 22516433 | 2012 | Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. |
| 20977675 | 2010 | TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor. |
| 20219906 | 2010 | Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. |
| 17981585 | 2008 | MSPL/TMPRSS13. |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 11267681 | 2001 | Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung. |
