Tbio ADGRE3 Adhesion G protein-coupled receptor E3

Protein Summary

Description

Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q9BY15

Gene Name

• ADGRE3

Ensembl ID

• ENST00000253673
• ENSP00000253673
• ENSG00000131355
• ENST00000344373
• ENSP00000340758

Symbol

• EMR3
• EMR3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
tissue	0.66
cell line	0.59
tissue sample	0.52
trait	0.46

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G Protein-coupled Receptor E3

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G Protein-coupled Receptor E3

Protein / ... / Protease / Adhesion G Protein-coupled Receptor E3

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor E3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0