Tbio SLC4A5 Electrogenic sodium bicarbonate cotransporter 4

Protein Summary

Description

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BY07
• Q32MA7
• Q59EQ9
• Q8WXD3
• Q8WXD7
• Q96DS7
• Q96DS8
• Q9HBU5

Gene Name

• SLC4A5

Ensembl ID

• ENST00000346834
• ENSP00000251768
• ENSG00000188687
• ENST00000358683
• ENSP00000351513
• ENST00000377632
• ENSP00000366859
• ENST00000377634
• ENSP00000366861
• ENST00000394019
• ENSP00000377587
• ENST00000423644
• ENSP00000395804

Symbol

• NBC4
• NBC4
• NBCe2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
molecular function	0.81
protein domain	0.73
microRNA	0.62
gene perturbation	0.61

Protein Classes

PANTHER Classes

Protein / ... / Cation Transporter / Electrogenic Sodium Bicarbonate Cotransporter 4

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc4 Family Of Bicarbonate Transporters / Sodium-dependent Hco3- Transporters / Electrogenic Sodium Bicarbonate Cotransporter 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.75   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.75   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0