Property Summary

NCBI Gene PubMed Count 21
PubMed Score 24.34
PubTator Score 18.80

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
lung carcinoma 2844 3.09107624012518E-28
breast carcinoma 1614 8.607499180273E-15
juvenile dermatomyositis 1189 7.86785472851856E-9
Breast cancer 3099 2.20350424883812E-8
cystic fibrosis 1670 1.71238707477399E-6
pediatric high grade glioma 2712 7.01923251111221E-6
glioblastoma 5572 1.61160913243268E-5
interstitial cystitis 2299 5.55451640474415E-5
ovarian cancer 8492 6.13285248491265E-5
sarcoidosis 368 3.50262828918101E-4
ependymoma 2514 0.00238930825864413
atypical teratoid / rhabdoid tumor 4369 0.00273929665589381
astrocytic glioma 2241 0.00425473676835735
medulloblastoma, large-cell 6234 0.00494831953672876
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00630279065303834
pancreatic cancer 2300 0.00658178555331245
Pick disease 1893 0.0111668895559086
acute myeloid leukemia 785 0.0130288086374902
lung adenocarcinoma 2714 0.0208634374231863
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0239410085131844
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0297061618614602
subependymal giant cell astrocytoma 2287 0.0302540116886631
sonic hedgehog group medulloblastoma 1482 0.0316885293824015
oligodendroglioma 2849 0.0350184408045942



Accession Q9BXY8 B2R574 D3DXA2 F5H7H5 Q5JVV9
Symbols BEX1


  Ortholog (5)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG
Pig EggNOG Inparanoid

Pathway (1)

Gene RIF (12)

25490384 Bex2 affects the invasion and migration ability of glioma cells by regulating beta-catenin
23022184 Bex2 may be an important player during the development of glioma
22907646 Bex2 overexpression promoted cell migration and invasion in glioma cell lines.
22698742 Both BEX2 and INI1/hSNF5 mainly localized in cell nucleus.
21384344 BEX2 overexpression was associated with breast cancer.
20482821 BEX2 has a functional interplay with c-Jun and p65/RelA in breast cancer.
19835597 These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins.
19412433 BEX2 is implicated in oligodendroglioma biology.
17638883 a NGF/BEX2/NF-kappaB pathway is involved in regulating apoptosis in breast cancer cells and in modulating response to tamoxifen in primary tumors
17251904 Correlation between BEX2 expression and mixed lineage leukemia chromosomal aberrations are shown in the cell lines.

AA Sequence


Text Mined References (22)

PMID Year Title
25490384 2015 ?-catenin is involved in Bex2 down-regulation induced glioma cell invasion/migration inhibition.
25416956 2014 A proteome-scale map of the human interactome network.
23022184 2012 Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway.
22907646 2013 Bex2 is critical for migration and invasion in malignant glioma cells.
22698742 2012 [BEX2 regulates cell cycle through the interaction with INI1/hSNF5].
21384344 2012 A feedback loop between BEX2 and ErbB2 mediated by c-Jun signaling in breast cancer.
20482821 2010 BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.
19835597 2009 Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia.
19711341 2010 BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer.
19412433 2009 Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression.