Property Summary

NCBI Gene PubMed Count 33
PubMed Score 17.34
PubTator Score 16.14

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Crohn Disease 97
Mammary Neoplasms 410
Disease Target Count P-value
breast carcinoma 1614 4.7583665020544E-24
adrenocortical carcinoma 1427 9.99289010756768E-11
pilocytic astrocytoma 3086 5.62941498912793E-9
lung carcinoma 2844 5.32067707770995E-8
non-small cell lung cancer 2798 2.58684558159181E-7
primitive neuroectodermal tumor 3031 2.29172502987326E-6
Breast cancer 3099 3.63265840629098E-6
psoriasis 6685 1.1026089171537E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 2.17618642773706E-4
pediatric high grade glioma 2712 3.39320892457525E-4
posterior fossa group B ependymoma 1530 3.57059437593911E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 4.07463306555111E-4
glioblastoma 5572 5.23189863753566E-4
limb girdle muscular dystrophy 2A 156 0.00146276664902356
oligodendroglioma 2849 0.00285648346813861
group 4 medulloblastoma 1875 0.00294067858796743
invasive ductal carcinoma 2950 0.00384578393536653
pituitary cancer 1972 0.00410663369884586
fibroadenoma 557 0.00420498029974608
acute quadriplegic myopathy 1157 0.0061130612935398
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0063462181226139
astrocytic glioma 2241 0.00662528620422688
interstitial cystitis 2299 0.00693239182894879
ovarian cancer 8492 0.0163905192607579
cystic fibrosis 1670 0.0176656344360637
ulcerative colitis 2087 0.0222227102547863



Accession Q9BXY4 B2RC27 Q5VTV4 Q96K87
Symbols PWTSR


  Ortholog (11)

Gene RIF (9)

26733130 A genome-wide association study of bone mineral density (BMD) found a new BMD locus that harbors the PTCH1 gene, that associates with reduced spine BMD and the RSPO3 associates with increased spine BMD.
25531322 These findings suggest that aberrant RSPO3-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1-deficient lung ADs.
24847761 results suggest that the expression of RSPO fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
22895193 using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours
20935629 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
18978678 Observational study of gene-disease association. (HuGE Navigator)
12643280 a polymorphism in thrombospondin subtly but significantly sensitizes the calcium-binding repeats to removal of Ca2+ and thermal denaturation
12463421 the gene is a novel member of thrombospondin type I repeat supergene family (hPWTSR)

AA Sequence


Text Mined References (35)

PMID Year Title
26766444 2016 Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
26733130 2016 Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures.
25531322 2015 Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.
24945404 2014 Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
24847761 2014 RSPO fusion transcripts in colorectal cancer in Japanese population.
24431302 2014 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
24430505 2014 Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
24097068 2013 Discovery and refinement of loci associated with lipid levels.
23972371 2013 Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.
23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.