Tbio TDRD1 Tudor domain-containing protein 1

Protein Summary

Description

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]

Uniprot Accession IDs

• Q9BXT4
• A6NEN3
• A6NMN2
• B3KVI4
• B4E2L5
• D3DRC2
• Q4G0Y8
• Q6P518
• Q9H7B3

Gene Name

• TDRD1

Ensembl ID

• ENST00000251864
• ENSP00000251864
• ENSG00000095627

Symbol

• CT41.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.65
cell type or tissue	0.63
small molecule perturbation	0.55
cell line	0.54
transcription factor	0.52

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Tudor Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Nuclease / Tudor Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.51   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.51   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0