| Tbio | Asporin |
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]
Comments
| Disease | Target Count |
|---|---|
| Degenerative polyarthritis | 93 |
| Intervertebral disc disorder | 7 |
| Keloid | 34 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Osteoarthritis | 96 | 5.015 | 2.5 |
| Degenerative disc disease | 28 | 3.255 | 1.6 |
| Hypochondrogenesis | 3 | 3.015 | 1.5 |
| Disease | Target Count |
|---|---|
| Osteoarthritis susceptibility 3 | 1 |
| Disease | Target Count |
|---|---|
| Intervertebral disc disease | 6 |
| Osteoarthritis 3 | 1 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Anole lizard | OMA Inparanoid |
| PMID | Text |
|---|---|
| 26446945 | To test the associations of ASPN variations with risk of subsequent oncologic outcomes. |
| 26016288 | this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA |
| 25673058 | Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR signaling pathway. |
| 25371314 | Osteomodulin, osteoglycin, and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage. |
| 25030405 | Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population. |
| 24453179 | D14-PLAP-1 suppressed BMP-2 signal transduction more efficiently than D13-PLAP-1; stronger affinity of D14-PLAP-1 protein to BMP-2 compared with D13-PLAP-1 protein. D repeat polymorphism of PLAP-1/asporin has influence on functions of PDL cells. |
| 24441039 | Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment. |
| 24306268 | This meta-analysis shows that the ASPN D14, D13, and D15 alleles are not associated with the development of osteoarthritis in Europeans and Asians. [Meta-Analysis] |
| 24078942 | Our data suggest that the D15 asporin allele could be considered a knee osteoarthritis risk allele significant only for women in the Iranian population. |
| 24003854 | The asporin-encoding gene is a promising candidate as a susceptibility gene for osteoarthritis and degenerative disc disease. [Review] |
| More... |
MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFD 1 - 70 LFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK 71 - 140 IHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 141 - 210 GIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDI 211 - 280 ENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLF 281 - 350 NNPVKYWEMQPATFRCVLSRMSVQLGNFGM 351 - 380 //
| PMID | Year | Title |
|---|---|---|
| 26446945 | 2016 | Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. |
| 26016288 | [D-repeat polymorphism in the ASPN gene in knee osteoarthritis in females in Torreón, Coahuila. Case-control study]. | |
| 25673058 | 2015 | Asporin participates in gastric cancer cell growth and migration by influencing EGF receptor signaling. |
| 25371314 | 2015 | Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage. |
| 25031006 | 2014 | [Effect of light centrifugal force on the asporin gene expression in human periodontal ligament cells]. |
| 25030405 | 2014 | Association between single nucleotide polymorphisms of asporin (ASPN) and BMP5 with the risk of knee osteoarthritis in a Chinese Han population. |
| 24905804 | 2014 | High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells. |
| 24716474 | 2014 | Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility. |
| 24708694 | 2014 | The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science. |
| 24453179 | 2014 | Inhibitory effects of PLAP-1/asporin on periodontal ligament cells. |
| More... |
