Property Summary

NCBI Gene PubMed Count 28
Grant Count 18
R01 Count 12
Funding $1,034,130.14
PubMed Score 0.00
PubTator Score 6.70

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (1)

Disease Z-score Confidence
oligodendroglioma 2,849

Expression

  Differential Expression (1)

Disease log2 FC p
oligodendroglioma 1.100 0.010

Gene RIF (8)

PMID Text
24673604 EPI64, a candidate GAP that is specific for Rab27.
23248241 Data suggest that EPI64A and B, which are ubiquitously expressed members of the EPI64 subfamily, inactivate Ras and certain Rabs at the periphery of cells.
22219378 EPI64 regulates membrane trafficking both by stabilizing Arf6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing Rab8a-GTP levels.
20360009 analysis of recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain
18976975 Knockdown of TBC1 domain family, member 10A (TBC1D10A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells
18450757 EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to immunological synapse formation, most likely by participating in TCR transport to the immunological synapse
17145964 These data reveal that microvilli have distinct cytoskeletal subdomains and that EPI64 regulates microvillar structure.
16923811 EPI64 is a GTPase-activating protein specific for Rab27A

AA Sequence

MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGA      1 - 70
LEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDE     71 - 140
LDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHM    141 - 210
PAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFS    211 - 280
RTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQE    281 - 350
VVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG    351 - 420
SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSA    421 - 490
HHRSQESLTSQESEDTYL                                                        491 - 508
//

Text Mined References (34)

PMID Year Title
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25416956 2014 A proteome-scale map of the human interactome network.
24673604 2014 Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23248241 2013 All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22354992 2012 Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
22219378 2012 EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.
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