Tbio SPZ1 Spermatogenic leucine zipper protein 1

Protein Summary

Description

Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity). This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9BXG8
• B2RA21
• Q8N4P1
• Q8N7E9

Gene Name

• SPZ1

Ensembl ID

• ENST00000296739
• ENSP00000369611
• ENSG00000164299

Symbol

• TSP1
• CILD38
• NYD-TSP1
• PPP1R148

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
kinase perturbation	0.81
PubMedID	0.58
cell line	0.51
cell type or tissue	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0