Property Summary

NCBI Gene PubMed Count 11
PubMed Score 22.79
PubTator Score 8.32

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
tuberculosis 1563 2.44729128740348E-8
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00269176038415404
Disease Target Count Z-score Confidence
Human granulocytic anaplasmosis 8 3.293 1.6


  Differential Expression (2)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.429 0.003
tuberculosis 1.200 0.000


Accession Q9BX68 Q5TCW3 HINT-2
Symbols HIT-17



4INC   4INI   4NJX   4NJY   4NJZ   4NK0  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
S.cerevisiae EggNOG Inparanoid

Pathway (1)

Gene RIF (4)

23682076 Low HINT2 expression is associated with low response to therapy in endometrial cancer.
23659632 X-ray crystal structure of human HINT2 with and without bound AMP.
20877624 Observational study of gene-disease association. (HuGE Navigator)
18653718 Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria.

AA Sequence

GAQSVYHLHIHVLGGRQLQWPPG                                                   141 - 163

Text Mined References (15)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23682076 2013 Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.
23659632 2013 Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
18653718 2008 Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16762638 2006 Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma.
16341674 2005 Transcriptome analysis of human gastric cancer.