Tbio SCRT1 Transcriptional repressor scratch 1

Protein Summary

Description

Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9BWW7
• A8MX66
• Q96C52

Gene Name

• SCRT1

Ensembl ID

• ENST00000569446
• ENSP00000455711
• ENSG00000261678

Symbol

• SCRT
• ZNF898

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.73
kinase perturbation	0.66
transcription factor	0.62
biological process	0.6
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 24   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.71   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0