Property Summary

NCBI Gene PubMed Count 32
PubMed Score 214.67
PubTator Score 21.64

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 2.19533600891801E-13
astrocytoma 1493 3.67702287918887E-13
glioblastoma 5572 9.90654385710046E-12
atypical teratoid/rhabdoid tumor 1095 9.99948986463056E-12
oligodendroglioma 2849 6.00981459925486E-10
pediatric high grade glioma 2712 6.08709191465626E-10
group 3 medulloblastoma 2254 2.10892997421835E-8
pituitary cancer 1972 1.78538583650714E-7
pilocytic astrocytoma 3086 8.52088375197012E-7
medulloblastoma, large-cell 6234 4.97420496663515E-4
primitive neuroectodermal tumor 3031 7.14734415996853E-4
non diabetic and post-ischemic heart failure 200 0.00116758130755986
Pick disease 1893 0.00674791637515706
type II diabetes mellitus and post-ischemic heart failure 89 0.0117478543402274
subependymal giant cell astrocytoma 2287 0.0121464776328524
interstitial cystitis 2299 0.0128010264573257
aldosterone-producing adenoma 664 0.0261211933510486
cutaneous lupus erythematosus 1056 0.0275607583551283
active ulcerative colitis 477 0.0292539427497019
active Crohn's disease 918 0.0326531671940172
Disease Target Count Z-score Confidence
Obesity 616 3.848 1.9



Accession Q9BWQ8 A8K1W6 B3KR08 Q9UJY9 Q9Y2F7
Symbols LFG


  Ortholog (10)

 GWAS Trait (1)

Gene RIF (21)

26398169 The interaction of TRIM21 and LFG was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.
25922107 There are significant differences in the associations of the FAIM2 promoter methylation with sedentary behaviour and physical activity between obese and lean children.
25764978 These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues
25735388 Low KRT13 mRNA expression is associated with oral squamous cell carcinoma.
25696115 Methylation levels of the FAIM2 promoter are significantly associated with obesity and are independently associated with dyslipidaemia and its components in Chinese children.
25069766 Results indicated that FAIM2 beta-isoform is strongly expressed in breast tumour tissues. Fas sensitivity was reduced in the MCF10A breast cells expressing the FAIM2 beta-isoform.
24621099 This study highlighted the importance of two candidate genes, SH2B1 and FAIM2, in the risk of overweight/obesity.
24393375 A polymorphism in FAIM2 is associated with higher myocardial infarction risk in type-2 diabetes mellitus subjects.
24335530 Faim2 is physiologically expressed in brain in bacterial meningitis.
23924573 The rs7138803 variant of FAIM2 was found to exert no effect on obesity in a Chinese Han population.

AA Sequence

RHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE                                      281 - 316

Text Mined References (35)

PMID Year Title
26398169 2015 TRIM21, a negative modulator of LFG in breast carcinoma MDA-MB-231 cells in vitro.
25922107 2015 Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study.
25764978 2015 The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²?-filling state.
25735388 2015 KRT13, FAIM2 and CYP2W1 mRNA expression in oral squamous cell carcinoma patients with risk habits.
25696115 2015 Promoter methylation of fas apoptotic inhibitory molecule 2 gene is associated with obesity and dyslipidaemia in Chinese children.
25069766 2014 Role of lifeguard ?-isoform in the development of breast cancer.
24621099 2014 Meta-analyses between 18 candidate genetic markers and overweight/obesity.
24393375 2014 Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial.
24335530 2014 Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis.
23924573 2013 Common rs7138803 variant of FAIM2 and obesity in Han Chinese.