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Tbio
RBM4
RNA-binding protein 4

Protein Summary
Description
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310092
  • ENSP00000309166
  • ENSG00000173933
  • ENST00000396053
  • ENSP00000413497
  • ENST00000398692
  • ENSP00000381680
  • ENST00000408993
  • ENSP00000386561
  • ENST00000409406
  • ENSP00000386894
  • ENST00000483858
  • ENSP00000435821
  • ENST00000530235
  • ENSP00000432150
  • ENST00000532968
  • ENSP00000432020

Symbol
  • RBM4A
  • LARK
  • RBM4A
  • ZCRB3A
  • ZCCHC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
biological process
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.56   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.56   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0