You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NUDT9
ADP-ribose pyrophosphatase, mitochondrial

Protein Summary
Description
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302174
  • ENSP00000303575
  • ENSG00000170502
  • ENST00000473942
  • ENSP00000421811

Symbol
  • NUDT10
  • NUDT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.78
virus perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0