You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RUSC1
RUN and SH3 domain-containing protein 1

Protein Summary
Description
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292254
  • ENSP00000292254
  • ENSG00000160753
  • ENST00000368347
  • ENSP00000357331
  • ENST00000368349
  • ENSP00000357333
  • ENST00000368352
  • ENSP00000357336
  • ENST00000368354
  • ENSP00000357338

Symbol
  • NESCA
  • NESCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
cellular component
0.64
tissue sample
0.62
cell line
0.59
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.37   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.37   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0