Property Summary

NCBI Gene PubMed Count 18
PubMed Score 11.52
PubTator Score 18.88

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Peripheral Neuropathy 303
Disease Target Count P-value
tuberculosis 1563 2.39883812884958E-9
ovarian cancer 8492 1.62730459184808E-6
acute quadriplegic myopathy 1157 1.62569130542463E-4
primitive neuroectodermal tumor 3031 0.0277864028173885
Disease Target Count Z-score Confidence
Neuronal intestinal dysplasia 6 4.964 2.5
Dental enamel hypoplasia 12 3.176 1.6


  Differential Expression (4)

Disease log2 FC p
primitive neuroectodermal tumor -1.100 0.028
acute quadriplegic myopathy 1.169 0.000
tuberculosis 1.800 0.000
ovarian cancer 1.600 0.000


Accession Q9BVJ7 Q9NX48
Symbols VHZ



2IMG   4ERC  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (6)

20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20509867 The upregulation of VHZ levels in primary human cancers supports the clinical relevance of this protein in cancers
20453000 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
15201283 the smallest active protein-tyrosine phosphatase yet (only 16 kDa) belongs to the group of small Vaccinia virus VH1-related dual specific phosphatases; gene is located on human chromosome 1q23.1 and consists of only two coding exons
15147733 DUSP23 showed distinctive phosphatase activity toward p-nitrophenyl phosphate, as well as oligopeptides containing phospho-tyrosine and phospho-threonine residues. Furthermore, DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in vitro

AA Sequence

AVFQFYQRTK                                                                141 - 150

Text Mined References (21)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24531476 2014 The family-wide structure and function of human dual-specificity protein phosphatases.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22939635 2012 Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
21787189 2011 Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data.
21269460 2011 Initial characterization of the human central proteome.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20509867 2010 VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers.
20453000 2010 A Large-scale genetic association study of esophageal adenocarcinoma risk.