Tbio ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Protein Summary

Description

Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• Q9BV57
• D6W4Y3
• Q53HW3
• Q53QD3
• Q57YV7
• Q68CK2
• Q6ZSF7
• Q7Z512
• Q96P85
• Q9NV57

Gene Name

• ADI1

Ensembl ID

• ENST00000327435
• ENSP00000333666
• ENSG00000182551
• ENST00000382093
• ENSP00000371525

Symbol

• MTCBP1
• ARD
• APL1
• SIPL
• mtnD
• Fe-ARD
• MTCBP1
• Ni-ARD
• HMFT1638

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
histone modification site profile	0.86
kinase perturbation	0.71
tissue	0.71
tissue sample	0.69

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / 1,2-dihydroxy-3-keto-5-methylthiopentene Dioxygenase

DTO Classes

Protein / Enzyme / Oxidoreductase / 1,2-dihydroxy-3-keto-5-methylthiopentene Dioxygenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.96   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 277   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.96   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0