Tbio MRI1 Methylthioribose-1-phosphate isomerase

Protein Summary

Description

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9BV20
• Q8NDC9
• M1Pi

Gene Name

• MRI1

Ensembl ID

• ENST00000040663
• ENSP00000040663
• ENSG00000037757
• ENST00000319545
• ENSP00000314871

Symbol

• MRDI
• M1Pi
• MRDI
• MTNA
• Ypr118w

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
kinase perturbation	0.66
transcription factor binding site profile	0.61
transcription factor perturbation	0.61
disease	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.77   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.77   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0