Property Summary

NCBI Gene PubMed Count 9
PubMed Score 8.58
PubTator Score 3.61

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
osteosarcoma 7933 2.58829679138531E-9
tuberculosis and treatment for 6 months 686 8.98718368833668E-6
malignant mesothelioma 3163 4.0309816113108E-5
astrocytic glioma 2241 0.0249855124963643
oligodendroglioma 2849 0.0258417102384828
group 3 medulloblastoma 2254 0.035296798646897
ependymoma 2514 0.0395847290167439

Expression

  Differential Expression (7)

Disease log2 FC p
malignant mesothelioma 2.600 0.000
astrocytic glioma -1.100 0.025
ependymoma -1.200 0.040
oligodendroglioma -1.100 0.026
osteosarcoma 2.591 0.000
tuberculosis and treatment for 6 months -1.200 0.000
group 3 medulloblastoma 1.200 0.035

Synonym

Accession Q9BUE0 D3DPM1 Q9NXU9
Symbols p28b

Gene

  Ortholog (10)

Gene RIF (2)

PMID Text
24840924 A novel transcriptional repression mechanism of hMED18 mediated by hCDK8 and further a novel positive role of free CDK/cyclin module in transcriptional activation is described.
22622162 HIV-1 Tat 47-59 peptide upregulates gene expression of mediator complex subunit 18 (MED18) in U-937 macrophages

AA Sequence

MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVL      1 - 70
RARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGI     71 - 140
MKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQDMVSDDMKNFAEQLKPLVHLEKIDPKRLM      141 - 208
//

Text Mined References (14)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24882805 2014 Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.
24840924 2014 Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15989967 2005 MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15175163 2004 A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
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