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Tbio
SPON2
Spondin-2

Protein Summary
Description
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290902
  • ENSP00000290902
  • ENSG00000159674
  • ENST00000431380
  • ENSP00000394832
  • ENST00000617421
  • ENSP00000483599

Symbol
  • DIL1
  • DIL1
  • DIL-1
  • MINDIN
  • M-SPONDIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.76
tissue sample
0.68
cell type or tissue
0.67
biological process
0.6
gene perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.99   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.99   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0